Margo Humphrey was born in Oakland, CA. She was awarded an undergraduate Fellowship to The Whitney Museum of American Art Summer Program in 1971. Humphrey earned a BFA in Painting and Printmaking and a MFA in Printmaking. She was one of the first African American women to distinguish herself in lithography.
Humphrey has been awarded three Teaching Fellowships from the United States Information Agency Arts America Program to demonstrate and teach various techniques in printmaking Fine Art. Margo Humphrey was honored with an invitation from the Nigerian Government to be the first artist to open the American section of the Nigerian National Gallery of Art.